{"id":156769,"date":"2025-07-28T15:21:14","date_gmt":"2025-07-28T13:21:14","guid":{"rendered":"https:\/\/cavalor.com\/?post_type=articles&p=156769"},"modified":"2025-07-28T16:09:41","modified_gmt":"2025-07-28T14:09:41","slug":"insulin-dysregulation-protein-metabolism","status":"publish","type":"articles","link":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/","title":{"rendered":"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism"},"content":{"rendered":"\n

Published in:\u00a0Somestic Animal Endocrinology<\/a><\/em>, Volume 92 – July 2025<\/p>\n\n\n\n

<\/div>\n\n\n\n

Current understanding of insulin dysregulation and its relationship with carbohydrate and protein metabolism in horses<\/h3>\n\n\n\n

Abstract<\/strong><\/p>\n\n\n\n

Insulin dysregulation (ID) is a common metabolic disorder in horses, characterized by hyperinsulinemia and\/or peripheral insulin resistance. The critical role of hyperinsulinemia in endocrinopathic laminitis has driven research into the insulinotropic effects of dietary nutrients and the reciprocal impact of ID on nutrient metabolism. The relationship between ID and carbohydrate metabolism has been extensively studied; however, the effects of ID on protein metabolism in horses remain largely unexplored. This review begins with an overview of the importance of insulin in the regulation of muscle protein synthesis and degradation and then examines the current understanding of the interplay between ID and protein and carbohydrate metabolism in horses. Horses with ID exhibit altered resting plasma amino acid concentrations and shifts in postprandial amino acid dynamics. Recent work illustrated that ID horses had higher levels of plasma amino acids following a protein meal and delayed postprandial clearance from the blood compared to non-ID horses. The postprandial muscle synthetic response does not seem to be diminished in ID horses, but alterations in key cellular signaling molecules have been reported. ID horses display a pronounced hyperinsulinemic response following the consumption of feeds providing a range of protein, non-structural carbohydrate, starch and water-soluble carbohydrate intakes. Recent studies have shown that ID horses have an increased postprandial incretin response, contributing to the observed hyperinsulinemia. To minimize the postprandial insulin response, thresholds for carbohydrate consumption have recently been proposed. Similar thresholds should be established for protein to aid in the refinement of nutritional strategies to manage ID horses.<\/p>\n\n\n\n

Authors:\u00a0Caroline M M Loos<\/a>,\u00a0<\/strong>K.L. Urschel<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Click for full publication in Domestic Animal Endocrinology<\/a><\/div>\n<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Published in:\u00a0Somestic Animal Endocrinology, Volume 92 – July 2025 Current understanding of insulin dysregulation and its relationship with carbohydrate and protein metabolism in horses Abstract Insulin dysregulation (ID) is a common metabolic disorder in horses, characterized by hyperinsulinemia and\/or peripheral insulin resistance. The critical role of hyperinsulinemia in endocrinopathic laminitis has driven research into the […]<\/p>\n","protected":false},"author":3770,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","main-structure":[1717],"reference-activation":[],"search-archive":[],"bezorgdheden":[612],"general-category":[],"_hot_topics":[],"class_list":["post-156769","articles","type-articles","status-publish","hentry","main-structure-research-en-us"],"yoast_head":"\nCavalor articles - Read more about nutrition and health<\/title>\n<meta name=\"description\" content=\"Discover all about horse nutrition, health and care in our Cavalor articles. Practical tips, scientific insights and inspiration for every rider.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism\" \/>\n<meta property=\"og:description\" content=\"Discover all about horse nutrition, health and care in our Cavalor articles. Practical tips, scientific insights and inspiration for every rider.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/\" \/>\n<meta property=\"og:site_name\" content=\"Cavalor\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/yourcavalor\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-28T14:09:41+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@cavalor\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/\"},\"author\":{\"name\":\"Caroline Loos\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#\\\/schema\\\/person\\\/064a0bf0d42f6c88111ca281698694b1\"},\"headline\":\"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism\",\"datePublished\":\"2025-07-28T13:21:14+00:00\",\"dateModified\":\"2025-07-28T14:09:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/\"},\"wordCount\":299,\"publisher\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#organization\"},\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/\",\"url\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/\",\"name\":\"Cavalor articles - Read more about nutrition and health\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#website\"},\"datePublished\":\"2025-07-28T13:21:14+00:00\",\"dateModified\":\"2025-07-28T14:09:41+00:00\",\"description\":\"Discover all about horse nutrition, health and care in our Cavalor articles. Practical tips, scientific insights and inspiration for every rider.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/insulin-dysregulation-protein-metabolism\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Articles\",\"item\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/articles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#website\",\"url\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/\",\"name\":\"Cavalor\",\"description\":\"Nutrition for horses\",\"publisher\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#organization\",\"name\":\"Cavalor\",\"url\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/cavalor.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/cavalor-logo.png\",\"contentUrl\":\"https:\\\/\\\/cavalor.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/cavalor-logo.png\",\"width\":696,\"height\":696,\"caption\":\"Cavalor\"},\"image\":{\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/yourcavalor\",\"https:\\\/\\\/x.com\\\/cavalor\",\"https:\\\/\\\/nl.linkedin.com\\\/company\\\/cavalor\",\"https:\\\/\\\/www.youtube.com\\\/user\\\/CavalorVideo\"],\"description\":\"From the first steps in the world of equestrian sport to the ultimate partnership of horse and rider: we are here to accompany you on your journey. We assist you in making the right feed decisions to bring out the best in you and your horse. Not as a quick fix, but with a view to the horizon. We\u2019re committed to good health inside and out. Our products are created to meet the needs of your horse in any sport, any phase of life, and any specific requirements. Ambition is what drives us and makes us grow. All of us. At Cavalor, we challenge ourselves to gain more knowledge and improve continuously. That\u2019s how we develop our products; every product is borne of a rational and unique view on equine feeding and care \u2013 supported by scientific research and driven by the desire for the health of the horse and the meeting of its needs.\",\"email\":\"info@cavalor.com\",\"telephone\":\"+32 (0)9 220 25 25\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/#\\\/schema\\\/person\\\/064a0bf0d42f6c88111ca281698694b1\",\"name\":\"Caroline Loos\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1c89acb9a1a12ad1409f3d8bcf0842ea830a8e2dee3ca9042cbdc83059d216aa?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1c89acb9a1a12ad1409f3d8bcf0842ea830a8e2dee3ca9042cbdc83059d216aa?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1c89acb9a1a12ad1409f3d8bcf0842ea830a8e2dee3ca9042cbdc83059d216aa?s=96&d=mm&r=g\",\"caption\":\"Caroline Loos\"},\"sameAs\":[\"https:\\\/\\\/cavalor.com\"],\"url\":\"https:\\\/\\\/cavalor.com\\\/en-us\\\/author\\\/caroline\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Cavalor articles - Read more about nutrition and health","description":"Discover all about horse nutrition, health and care in our Cavalor articles. Practical tips, scientific insights and inspiration for every rider.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/","og_locale":"en_US","og_type":"article","og_title":"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism","og_description":"Discover all about horse nutrition, health and care in our Cavalor articles. Practical tips, scientific insights and inspiration for every rider.","og_url":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/","og_site_name":"Cavalor","article_publisher":"https:\/\/www.facebook.com\/yourcavalor","article_modified_time":"2025-07-28T14:09:41+00:00","twitter_card":"summary_large_image","twitter_site":"@cavalor","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/#article","isPartOf":{"@id":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/"},"author":{"name":"Caroline Loos","@id":"https:\/\/cavalor.com\/en-us\/#\/schema\/person\/064a0bf0d42f6c88111ca281698694b1"},"headline":"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism","datePublished":"2025-07-28T13:21:14+00:00","dateModified":"2025-07-28T14:09:41+00:00","mainEntityOfPage":{"@id":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/"},"wordCount":299,"publisher":{"@id":"https:\/\/cavalor.com\/en-us\/#organization"},"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/","url":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/","name":"Cavalor articles - Read more about nutrition and health","isPartOf":{"@id":"https:\/\/cavalor.com\/en-us\/#website"},"datePublished":"2025-07-28T13:21:14+00:00","dateModified":"2025-07-28T14:09:41+00:00","description":"Discover all about horse nutrition, health and care in our Cavalor articles. Practical tips, scientific insights and inspiration for every rider.","breadcrumb":{"@id":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cavalor.com\/en-us\/articles\/insulin-dysregulation-protein-metabolism\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cavalor.com\/en-us\/"},{"@type":"ListItem","position":2,"name":"Articles","item":"https:\/\/cavalor.com\/en-us\/articles\/"},{"@type":"ListItem","position":3,"name":"RESEARCH Article: Insulin Dysregulation, Carbohydrates and Protein Metabolism"}]},{"@type":"WebSite","@id":"https:\/\/cavalor.com\/en-us\/#website","url":"https:\/\/cavalor.com\/en-us\/","name":"Cavalor","description":"Nutrition for horses","publisher":{"@id":"https:\/\/cavalor.com\/en-us\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cavalor.com\/en-us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cavalor.com\/en-us\/#organization","name":"Cavalor","url":"https:\/\/cavalor.com\/en-us\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cavalor.com\/en-us\/#\/schema\/logo\/image\/","url":"https:\/\/cavalor.com\/wp-content\/uploads\/2025\/03\/cavalor-logo.png","contentUrl":"https:\/\/cavalor.com\/wp-content\/uploads\/2025\/03\/cavalor-logo.png","width":696,"height":696,"caption":"Cavalor"},"image":{"@id":"https:\/\/cavalor.com\/en-us\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/yourcavalor","https:\/\/x.com\/cavalor","https:\/\/nl.linkedin.com\/company\/cavalor","https:\/\/www.youtube.com\/user\/CavalorVideo"],"description":"From the first steps in the world of equestrian sport to the ultimate partnership of horse and rider: we are here to accompany you on your journey. We assist you in making the right feed decisions to bring out the best in you and your horse. Not as a quick fix, but with a view to the horizon. We\u2019re committed to good health inside and out. Our products are created to meet the needs of your horse in any sport, any phase of life, and any specific requirements. Ambition is what drives us and makes us grow. All of us. At Cavalor, we challenge ourselves to gain more knowledge and improve continuously. That\u2019s how we develop our products; every product is borne of a rational and unique view on equine feeding and care \u2013 supported by scientific research and driven by the desire for the health of the horse and the meeting of its needs.","email":"info@cavalor.com","telephone":"+32 (0)9 220 25 25"},{"@type":"Person","@id":"https:\/\/cavalor.com\/en-us\/#\/schema\/person\/064a0bf0d42f6c88111ca281698694b1","name":"Caroline Loos","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/1c89acb9a1a12ad1409f3d8bcf0842ea830a8e2dee3ca9042cbdc83059d216aa?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/1c89acb9a1a12ad1409f3d8bcf0842ea830a8e2dee3ca9042cbdc83059d216aa?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1c89acb9a1a12ad1409f3d8bcf0842ea830a8e2dee3ca9042cbdc83059d216aa?s=96&d=mm&r=g","caption":"Caroline Loos"},"sameAs":["https:\/\/cavalor.com"],"url":"https:\/\/cavalor.com\/en-us\/author\/caroline\/"}]}},"_links":{"self":[{"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/articles\/156769","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/users\/3770"}],"replies":[{"embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/comments?post=156769"}],"version-history":[{"count":0,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/articles\/156769\/revisions"}],"wp:attachment":[{"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/media?parent=156769"}],"wp:term":[{"taxonomy":"main-structure","embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/main-structure?post=156769"},{"taxonomy":"reference-activation","embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/reference-activation?post=156769"},{"taxonomy":"search-archive","embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/search-archive?post=156769"},{"taxonomy":"bezorgdheden","embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/bezorgdheden?post=156769"},{"taxonomy":"general-category","embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/general-category?post=156769"},{"taxonomy":"_hot_topics","embeddable":true,"href":"https:\/\/cavalor.com\/en-us\/wp-json\/wp\/v2\/_hot_topics?post=156769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}